RTRAF (Q9Y224) - Overview - Molecular Target Synopsis
RTRAF, RNA transcription, translation and transport factor protein
Also Known as RTRAF_HUMAN, RTRAF, C14orf166
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264)., (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157). Homodimer (Probable). Interacts with FAM98A (via N- and C-terminus) (PubMed:28040436). Interacts with NIN; which may prevent phosphorylation of NIN (PubMed:15147888). Interacts with POLR2A (PubMed:16950395). Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB (PubMed:21311021, PubMed:24870230, PubMed:24608264).
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UniProt: RTRAF is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus, perinuclear region.
GO terms: RTRAF is active in the following subcellular-locations: centrosome, cytoplasm, cytosol, mitotic spindle, nucleoplasm, nucleus, perinuclear region of cytoplasm, tRNA-splicing ligase complex.