Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RTRAF (Q9Y224) - Overview - Molecular Target Synopsis

Protein


RTRAF, RNA transcription, translation and transport factor protein
UniProt Q9Y224

Also Known as RTRAF_HUMAN, RTRAF, C14orf166

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264)., (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157). Homodimer (Probable). Interacts with FAM98A (via N- and C-terminus) (PubMed:28040436). Interacts with NIN; which may prevent phosphorylation of NIN (PubMed:15147888). Interacts with POLR2A (PubMed:16950395). Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB (PubMed:21311021, PubMed:24870230, PubMed:24608264).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RTRAF is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus, perinuclear region.
GO terms: RTRAF is active in the following subcellular-locations: centrosome, cytoplasm, cytosol, mitotic spindle, nucleoplasm, nucleus, perinuclear region of cytoplasm, tRNA-splicing ligase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RTRAF has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)