Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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TRPC6 (Q9Y210) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5YX9_B Short transient receptor potential channel 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 73.3 52.9 Yes Yes
2 empty 2.3 65.2 59.7 No No
3 empty 2.2 67.2 41.2 No No
4 empty 1.37 61.3 32 No No
5 empty 2.23 51 27.1 No No
6 empty 2.34 62.6 22.7 No No
7 empty 2.17 60.7 21.7 No No
8 empty 1.17 69.8 22.1 No No
9 empty 2.5 60 22.3 No No
10 empty 2.58 62.8 17.4 No No
5YX9_A Short transient receptor potential channel 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 72.1 53.3 Yes Yes
2 empty 2.27 66.2 58.2 No No
3 empty 2.13 67 38.6 No No
4 empty 1.73 71.5 33.4 No No
5 empty 1.24 63.1 28.5 No No
6 empty 2.28 62.2 21.6 No No
7 empty 2.18 58.2 21.4 No No
8 empty 2.12 57.7 23.1 No No
9 empty 2.29 58.8 28.7 No No
10 empty 1.02 69.6 22.1 No No
5YX9_D Short transient receptor potential channel 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 74 51.3 Yes Yes
2 empty 2.27 66.9 51.2 No No
3 empty 2.16 66.7 39.9 No No
4 empty 1.26 64 29.2 No No
5 empty 2.29 63.8 28.8 No No
6 empty 2.14 51.8 25.6 No No
7 empty 2.1 57.7 23.3 No No
8 empty 2.39 62.4 26.8 No No
9 empty 1.04 67.8 22.6 No No
10 empty 2.56 58.7 18.8 No No
5YX9_C Short transient receptor potential channel 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 73.6 66.1 Yes Yes
2 empty 2.3 67.3 59 No No
3 empty 2 66.9 32.3 No No
4 empty 1.28 61.1 32.2 No No
5 empty 2.27 62.7 29.4 No No
6 empty 2.12 51.1 26.3 No No
7 empty 2.35 61.1 27.2 No No
8 empty 1.07 66.4 22.5 No No
9 empty 2.5 62.5 15.2 No No
10 empty .74 67 15.5 No No
Ligand-based Druggability Score: -0.3
Ligand-based Druggability Score Percentile: 76%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


TRPC6 is involved in 10 interactions in the network.


Druggability
Overall Druggability Percentile: 83.29
Druggability for Cancer Therapeutics: 84.49
Druggability for Other Therapeutics: 89.58
Cancer-Associated
Cancer-associated percentile : 77.94
Network Articulation Point
Is TRPC6 critical for communication in the network?


Detailed Graph Legend:Help