Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPC6 (Q9Y210) - Overview - Molecular Target Synopsis

Protein


TRPC6, Short transient receptor potential channel 6
UniProt Q9Y210

Also Known as TRPC6_HUMAN, TRPC6, TRP6

Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. Homodimer; forms channel complex (PubMed:26892346). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865).

5YX9
CRYO-EM STRUCTURE OF HUMAN TRPC6 AT 3.8A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for TRPC6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPC6 is active in the following subcellular-locations: cell membrane.
GO terms: TRPC6 is active in the following subcellular-locations: cation channel complex, cytoplasm, integral component of plasma membrane, membrane, plasma membrane, slit diaphragm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPC6 has gain in 12 cell-lines, loss in 6 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: IGROV1, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H727, OVMANA, CAL51

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


For TRPC6 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPC6 has been screened with 24 compounds (25 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)