Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRG15 (Q9Y0I1) - Overview - Molecular Target Synopsis

Protein


MRG15, NuA4 complex subunit EAF3 homolog
UniProt Q9Y0I1

Also Known as EAF3_DROME, MRG15

Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.

2LRQ
CHEMICAL SHIFT ASSIGNMENT AND SOLUTION STRUCTURE OF FR822A FROM DROSOPHILA MELANOGASTER. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET FR822A
RCSB/PDB
Inspect Structure
See all 3D Structures for MRG15

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
424Q9Y0I1-1

Sub-cellular localization


UniProt: MRG15 is active in the following subcellular-locations: nucleus.
GO terms: MRG15 is active in the following subcellular-locations: histone acetyltransferase complex, histone methyltransferase complex, NuA4 histone acetyltransferase complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRG15 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For MRG15 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis