Molecular Target Synopsis
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colG (Q9X721) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1NQJ_B Collagenase ColG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 71.1 19.6 Yes Yes
2 empty 1.8 72 14.8 No No
3 empty 2.47 66 21.7 No No
4 empty 2.5 61.5 12.8 No No
5 empty 2.61 60.5 10.5 No No
6 empty 2 64.3 8.8 No No
7 empty 2.69 72.5 9.2 No No
8 empty 1.66 65.3 7.3 No No
9 empty 2.99 59.7 6.7 No No
10 empty 2.91 71.7 7.8 No No
5IKU_A Collagenase ColG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 70 35.6 Yes Yes
2 empty 2.25 64.7 31.4 No No
3 empty 2.19 64 14.9 No No
4 empty 2.69 67.4 14.1 No No
5 empty 2.17 63.2 11.9 No No
6 empty 2.63 61.6 11 No No
7 empty 2.31 62.5 13.7 No No
8 empty 2.34 54.1 14 No No
9 empty 2.38 65.4 12.7 No No
10 empty 2.13 66.1 10 No No
4TN9_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 58.2 12.9 No No
2 empty 2.13 61.7 16.5 No No
3 empty 2.65 58 13.7 No No
4 empty 2.3 67.7 10.1 No No
5 empty 2.24 64.7 10.6 No No
6 empty 2.71 51.6 9.5 No No
7 empty 2.45 66.7 4.8 No No
8 empty 3 65.2 5.3 No No
9 empty 2.42 71.1 5.3 No No
10 empty 2.32 59.3 4.9 No No
4ARE_A Collagenase ColG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 64 57.1 Yes No
2 empty 1.95 62.2 29.7 No No
3 bound 1.92 67.6 24.8 No No
4 empty 2.09 74.6 15.4 No No
5 empty 1.83 70.1 22.9 No No
6 empty 2.25 59.9 23.1 No No
7 empty 2.34 64.6 25.4 No No
8 empty 1.87 64.7 20.4 No No
9 empty 1.88 63.5 24.9 No No
10 empty 1.73 66.7 16.1 No No
4TN9_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.5 16.7 No No
2 empty 2.17 61.1 11.9 No No
3 empty 2.31 63.7 10.4 No No
4 empty 2.35 67.8 9 No No
5 empty 2.55 53.8 9.7 No No
6 empty 2.69 54.8 10.7 No No
7 empty 3.22 47 8.5 No No
8 empty 3.04 56.2 7.7 No No
9 empty 2.42 61.8 6.5 No No
10 empty 2.64 64.6 7 No No
4JRW_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 59.4 13 No No
2 empty 2.29 61.6 13.6 No No
3 empty 2.11 63.6 11.7 No No
4 empty 2.39 65.5 12.2 No No
5 empty 2.64 75.4 7.7 No No
6 empty 2.34 66 5.4 No No
7 empty 2.37 67.3 6.2 No No
8 empty 2.19 66.1 6.2 No No
9 empty 2.49 57.8 6.7 No No
1NQD_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 69.2 15.1 No No
2 empty 2.59 71 20.5 No No
3 empty 2.48 64.7 15.1 No No
4 empty 2.82 57.2 11.8 No No
5 empty 2.46 53.9 12.5 No No
6 empty 2.04 60.9 9.3 No No
7 empty 2.75 61.9 7.3 No No
8 empty 2.66 62.4 10 No No
9 empty 2.57 56.1 8.3 No No
10 empty 2.94 58.2 11.3 No No
2O8O_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 67.4 21.2 No No
2 empty 2.24 64.2 13.6 No No
3 empty 2.69 68.4 15.1 No No
4 empty 2.32 58.1 11.1 No No
5 empty 1.96 60.8 9.2 No No
6 empty 1.67 59.1 12.7 No No
7 empty 2.52 55.8 10.1 No No
8 empty 2.42 54.3 12 No No
9 empty 2.25 69.3 9.6 No No
10 empty 3 66.1 5 No No
1NQD_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 61.5 21.8 No No
2 empty 2.37 61.4 19.3 No No
3 empty 2.52 61 11.3 No No
4 empty 2.04 68.9 14.2 No No
5 empty 2.49 57.1 12.1 No No
6 empty 2.54 57.2 11.2 No No
7 empty 2.14 57.2 9.8 No No
8 empty 2.57 54.3 8.7 No No
9 empty 1.9 81.3 7.9 No No
10 empty 2.95 52.7 10.7 No No
4HPK_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 67.9 21.3 No No
2 empty 2.1 59.8 13.6 No No
3 empty 2.56 66.2 14.8 No No
4 empty 2.33 52.5 11.8 No No
5 empty 1.49 59 12.1 No No
6 empty 2.36 58.2 10.5 No No
7 empty 2.08 58.9 10.2 No No
8 empty 2.22 55.6 11.4 No No
9 empty 2.53 54.1 9.9 No No
10 empty 2.2 65.5 9.6 No No
4JRW_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 57.2 17.5 No No
2 empty 2.01 60.1 12.4 No No
3 empty 2.15 63.8 11.3 No No
4 empty 2.27 62.4 11.4 No No
5 empty 2.78 52.7 10.7 No No
6 empty 2.62 55.3 6.8 No No
7 empty 2.86 81.7 0 No No
8 empty 2.53 65.9 7.6 No No
9 empty 2.47 64.2 5.8 No No
10 empty 2.76 69.5 5.3 No No
4HPK_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 67.6 11.5 No No
2 empty 2.2 73.8 14.7 No No
3 empty 1.81 55.1 11.2 No No
4 empty 2.35 67.7 10.9 No No
5 empty 2.33 53.1 10.1 No No
6 empty 2.4 59.1 10 No No
7 empty 2.21 56.7 10 No No
8 empty 2.09 57.3 10.2 No No
9 empty 2.53 60.3 10 No No
10 empty 2.5 57.5 8.6 No No
4AQO_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 58.8 14.2 No No
2 empty 2.4 59.8 13.3 No No
3 empty 2.42 51.9 10.2 No No
4 empty 2.23 58.4 11 No No
5 empty 2.44 63.9 11.2 No No
6 empty 2.53 52.9 7.4 No No
7 empty 2.24 79 0 No No
8 empty 2.58 58.6 5.9 No No
1NQJ_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 69.9 15.6 No No
2 empty 2.71 60 12.9 No No
3 empty 1.85 71.4 10.2 No No
4 empty 2.11 57.8 9.1 No No
5 empty 1.6 68 11.6 No No
6 empty 1.77 60 10.5 No No
7 empty 2.47 59.4 10.6 No No
8 empty 2.34 51.1 10.4 No No
9 empty 2.75 62.7 7.3 No No
10 empty 2.89 67.1 0 No No
2Y3U_A Collagenase ColG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 64.1 24.8 Yes No
2 empty 1.57 62.5 23 No No
3 empty 2.09 56.2 26 No No
4 bound 1.91 65.4 21.3 No No
5 empty 1.92 58.9 18.1 No No
6 empty 2 62 18 No No
7 empty 2 76 16 No No
8 empty 2.16 56.9 21 No No
9 empty 2.06 60.9 17.2 No No
10 empty 2.2 63.2 13.3 No No
2O8O_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 64 17.5 No No
2 empty 2.12 73.5 13.3 No No
3 empty 2.33 66.9 10.3 No No
4 empty 2.31 52.5 12.5 No No
5 empty 2.52 62.9 10.3 No No
6 empty 2.47 66.4 11.9 No No
7 empty 1.82 59.2 9.7 No No
8 empty 2.9 62.1 9.3 No No
9 empty 2.08 56.7 10.1 No No
10 empty 2.39 54.8 8.3 No No
2Y6I_A Collagenase ColG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 64.7 59 Yes No
2 empty 1.96 63.2 31.5 No No
3 bound 1.86 73.6 25.1 No No
4 empty 2.12 72.1 24 No No
5 empty 2.2 60.9 21.9 No No
6 empty 1.88 65.4 31.3 No No
7 empty 1.89 66.9 30.2 No No
8 bound 2.1 64.5 23.6 No No
9 bound 1.79 70.3 19.2 No No
10 empty 2.31 65.7 15.9 No No
2Y72_B Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 54.7 16 No No
2 empty 2.1 65.7 12.2 No No
3 empty 1.92 61.4 10.3 No No
4 empty 2.22 66.7 8.6 No No
5 empty 2.39 66 11.2 No No
6 empty 2.55 67.1 10.4 No No
7 empty 2.78 59 7.7 No No
8 empty 3.29 63.5 6.4 No No
9 empty 2.15 51.7 5.6 No No
10 empty 2.78 61.9 5.9 No No
2Y50_A Collagenase ColG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 62.7 25.9 Yes No
2 bound 1.75 65.2 21.3 No No
3 empty 1.99 62.3 22.1 No No
4 empty 1.57 65.6 18.9 No No
5 empty 2.15 52.6 19.2 No No
6 empty 2.27 60.6 24.9 No No
7 empty 1.92 75.1 15.4 No No
8 empty 1.77 56.5 17.8 No No
9 empty 1.75 61.9 14.6 No No
10 empty 2.25 63.4 16.7 No No
2Y72_A Collagenase ColG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 54.8 13.7 No No
2 empty 2.05 58.4 10.6 No No
3 empty 2.53 63.4 10.9 No No
4 empty 2.36 63.8 9.9 No No
5 empty 2.24 64 9.5 No No
6 empty 2.35 51.2 11.2 No No
7 empty 2.24 74.5 8.3 No No
8 empty 2.27 62.9 7.8 No No
9 empty 2.15 64.2 6.5 No No
10 empty 3.38 58.8 5.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed14
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2Y3U_A (3600291) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9_N 2.55Å Yes Yes
2Y3U_A (3600292) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9 2.55Å Yes No
2Y3U_A (3600293) Collagenase ColG UNMATCHED, UNMATCHED, UNMATCHED 2Y3U 2.55Å Yes No
2Y50_A (3600357) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9_N 2.8Å Yes No
2Y50_A (3600358) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9 2.8Å Yes No
2Y50_A (3600359) Collagenase ColG UNMATCHED, UNMATCHED, UNMATCHED 2Y50 2.8Å Yes No
2Y6I_A (3600409) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9_N 3.25Å Yes No
2Y6I_A (3600411) Collagenase ColG UNMATCHED, UNMATCHED, UNMATCHED 2Y6I 3.25Å Yes No
2Y6I_A (3600410) Collagenase ColG PFAM, PFAM, PFAM Peptidase_M9 3.25Å Yes No
2Y72_A (3600424) Collagenase ColG Immunoglobulin-like beta-sandwich, PKD domain, UNMATCHED 1.18Å No No
3JQU_B (4006069) Collagenase ColG Immunoglobulin-like beta-sandwich, PKD domain, PKD domain 1.4Å No No
3JQU_A (4053405) Collagenase ColG Immunoglobulin-like beta-sandwich, PKD domain, PKD domain 1.4Å No No
3JS7_B (4079661) Collagenase ColG Immunoglobulin-like beta-sandwich, PKD domain, PKD domain 1.6Å No No
3JS7_A (4132300) Collagenase ColG Immunoglobulin-like beta-sandwich, PKD domain, PKD domain 1.6Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score