Molecular Target Synopsis
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(Q9X0Z6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed19
Chains with at least one site assessed as druggable using the strict criteria19
Chains with at least one site assessed as druggable using the relaxed criteria19


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4JXC_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 98.5 0 Yes Yes
2 bound 2.4 65 35.1 No No
3 bound 2.01 66.5 24.8 No No
4 empty 2.22 69 17.5 No No
5 empty 2.21 67.9 22.9 No No
6 empty 1.95 65.9 13.2 No No
7 empty 1.87 73 15.7 No No
8 empty 1.95 62.4 13.6 No No
9 empty 1.88 66 10.7 No No
10 empty 2.13 66.2 9.6 No No
5FEX_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 99.3 0 Yes Yes
2 bound 2.44 65.5 35.5 No No
3 empty 2.28 69.2 18.2 No No
4 empty 1.97 65.2 22.3 No No
5 empty 1.77 63.6 14.5 No No
6 empty 2.26 66.5 22.8 No No
7 empty 2.04 67 19.6 No No
8 empty 1.89 59.8 13.5 No No
9 empty 2.09 63.8 9.7 No No
10 empty 1.84 64.8 13 No No
5FEZ_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 99.1 0 Yes Yes
2 bound 2.42 64.8 36.3 No No
3 empty 2.14 68.9 18.6 No No
4 empty 1.99 67.2 19 No No
5 empty 1.8 65.1 13.1 No No
6 empty 2.02 63.3 16.1 No No
7 empty 1.94 68 14.2 No No
8 empty 2.25 66.1 22.6 No No
9 empty 2.04 63.4 15.2 No No
10 empty 2.08 67.7 9.9 No No
3IIX_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 83.9 33.6 Yes Yes
2 bound 2.49 63.8 35.3 No No
3 empty 2.29 68.3 17.7 No No
4 empty 2.09 68.2 18 No No
5 empty 2.21 67.2 13.3 No No
6 empty 1.78 64.5 13.3 No No
7 empty 2.05 71.2 14.1 No No
8 empty 1.93 61.9 13.2 No No
9 empty 1.87 64.4 15.1 No No
10 empty 1.94 81.1 10.2 No No
5FEP_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 97.4 0 Yes Yes
2 bound 2.13 58.6 25 No No
3 empty 2.16 61.3 19.4 No No
4 empty 2.09 64.4 17.1 No No
5 empty 1.74 61.6 14.6 No No
6 empty 1.91 63.4 10.8 No No
7 empty 2.87 69.5 10.5 No No
8 empty 2.03 61.2 10.9 No No
9 empty 1.89 63.9 11.9 No No
10 empty 1.87 56.4 9.2 No No
4JYE_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 99.2 0 Yes Yes
2 bound 2.52 64.8 36.2 No No
3 empty 2.26 66.6 17 No No
4 empty 2.15 65.8 15.3 No No
5 empty 1.79 65.7 14.1 No No
6 bound 1.83 58.3 23.5 No No
7 empty 2.05 70.7 14.9 No No
8 empty 1.95 68.6 14.7 No No
9 empty 1.85 60.7 13.6 No No
10 empty 2.11 72.2 11 No No
4JY9_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 98.8 0 Yes Yes
2 bound 2.45 65.7 34 No No
3 empty 2.24 66.4 18.5 No No
4 bound 1.92 61 18 No No
5 empty 2.22 67.5 15.1 No No
6 empty 1.95 67 14 No No
7 empty 2.02 72.2 14.4 No No
8 empty 1.86 64.7 13.1 No No
9 empty 2.05 60.1 18.3 No No
10 empty 2.1 68 10.5 No No
5FF0_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 99.5 0 Yes Yes
2 bound 2.55 64.6 35.3 No No
3 empty 2.18 66.2 18.2 No No
4 empty 2.05 65.7 20.2 No No
5 empty 1.81 63.3 14.5 No No
6 empty 2.07 67.4 18.6 No No
7 empty 1.98 66.2 11 No No
8 empty 2.24 66.2 12.8 No No
9 empty 1.94 74.5 14.5 No No
10 empty 1.92 62.6 11.9 No No
4JYD_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 98.5 0 Yes Yes
2 bound 2.12 62.3 27.3 No No
3 empty 2.26 68.1 18.2 No No
4 empty 1.73 62.9 17.4 No No
5 empty 2.15 67.6 20.5 No No
6 empty 2.25 71.4 16.6 No No
7 empty 1.98 72.8 15.7 No No
8 empty 2.06 66 13.3 No No
9 empty 2 62.5 11.6 No No
10 empty 2.66 70.5 10.2 No No
5FF3_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 98.8 0 Yes Yes
2 bound 2.37 64.8 35.9 No No
3 empty 2.26 65.5 17.3 No No
4 bound 2.14 63.6 25.3 No No
5 empty 1.97 64.3 14.5 No No
6 empty 2.04 72.1 14.3 No No
7 empty 2.21 66.7 16.8 No No
8 empty 1.92 63.2 11.6 No No
9 empty 1.86 65 12 No No
10 empty 1.98 79.8 10.3 No No
3IIZ_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 99.1 0 Yes Yes
2 bound 2.6 63.1 37.2 No No
3 bound 1.98 65.9 27.1 No No
4 empty 2.24 66.9 15.9 No No
5 empty 2.2 67 22.6 No No
6 empty 1.97 64.6 13.8 No No
7 empty 2 64.1 13.5 No No
8 empty 1.86 63.4 12.5 No No
9 empty 2.05 65.3 10.2 No No
10 empty 2.13 70.1 9.1 No No
5FES_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 99.6 0 Yes Yes
2 bound 2.46 64.5 35.4 No No
3 empty 2.05 66.4 27.7 No No
4 empty 2.26 69.6 18.6 No No
5 empty 1.81 66 13.3 No No
6 empty 2.17 65.6 22.3 No No
7 empty 1.98 66.6 10.4 No No
8 empty 1.89 60.4 13.5 No No
9 empty 1.84 64.4 13.3 No No
10 empty 2.21 67.1 15 No No
5FF4_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 99.1 0 Yes Yes
2 bound 2.46 64.7 35.2 No No
3 empty 1.99 67.6 21.8 No No
4 empty 2.22 66.2 16.9 No No
5 empty 1.8 69.2 19.1 No No
6 empty 1.81 63.5 13.3 No No
7 empty 2.02 67.3 12.6 No No
8 empty 2.29 66.5 16.8 No No
9 empty 2 63.5 13.1 No No
10 empty 1.86 63.8 13.2 No No
5FF2_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 99.4 0 Yes Yes
2 bound 2.21 63 27.3 No No
3 empty 2.29 67.6 17.9 No No
4 empty 2.17 70 21.3 No No
5 empty 1.74 65.1 18.6 No No
6 empty 1.93 62.3 16.4 No No
7 empty 2.1 69.5 15.3 No No
8 empty 2.25 67.2 22.6 No No
9 empty 1.96 61.4 14 No No
10 empty 2.69 70.2 9.3 No No
3CIX_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 98.7 0 Yes Yes
2 bound 2.13 60.8 28.1 No No
3 empty 2.23 63.9 18.2 No No
4 empty 2.19 66.7 14 No No
5 bound 1.78 60.9 18.2 No No
6 empty 1.76 64.2 14.3 No No
7 empty 2.24 68.4 12 No No
8 empty 2.01 64.5 14.6 No No
9 empty 2.8 72.5 9.6 No No
10 empty 2.19 65.7 10.4 No No
5FEW_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 99.6 0 Yes Yes
2 bound 2.41 65.3 36.3 No No
3 empty 2.27 68.1 18.6 No No
4 empty 1.99 69 18.7 No No
5 empty 2.16 65.9 11.5 No No
6 empty 2.01 67 13.2 No No
7 empty 2.16 65.5 21.2 No No
8 empty 1.9 65.2 10.8 No No
9 empty 1.87 61.2 13.4 No No
10 empty 1.85 64.5 13 No No
3CIW_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 99.1 0 Yes Yes
2 bound 2.47 62.9 35.9 No No
3 empty 2.26 67 17.7 No No
4 empty 2.2 67.2 17.7 No No
5 empty 1.96 66.7 12.9 No No
6 empty 2.03 67.5 15.3 No No
7 empty 1.94 68.7 12.7 No No
8 empty 1.92 63.5 12.2 No No
9 empty 1.86 63.8 13 No No
10 empty 2.19 70.4 14.4 No No
4JYF_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 83.9 33.7 Yes Yes
2 bound 2.49 63.7 37.2 No No
3 empty 2.27 65.8 17.7 No No
4 empty 1.79 66.5 13.7 No No
5 empty 2.05 69.9 14 No No
6 empty 2.28 67.7 9.8 No No
7 empty 1.86 64.1 14.7 No No
8 empty 2.01 64.3 16.9 No No
9 empty 2.2 73.7 11.5 No No
10 empty 1.84 79.3 10.6 No No
4JY8_A [FeFe] hydrogenase maturase subunit HydE Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 86.2 30 Yes Yes
2 bound 1.62 72.2 17.3 Yes No
3 empty 1.6 64 22 No No
4 empty 1.8 67.4 12.6 No No
5 empty 2.24 66.1 15.2 No No
6 empty 2.17 65.3 13.6 No No
7 empty 2.24 70.3 17.3 No No
8 empty 1.69 66.7 13.4 No No
9 empty 2.34 70.7 8.7 No No
10 bound 1.9 73.3 15.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3CIW_A (3340212) [FeFe] hydrogenase maturase subunit HydE TIM beta/alpha-barrel, Radical SAM enzymes, UNMATCHED 1.35Å Yes Yes
3CIW_A (3340213) [FeFe] hydrogenase maturase subunit HydE UNMATCHED, UNMATCHED, UNMATCHED 3CIW 1.35Å Yes No
3CIX_A (3340214) [FeFe] hydrogenase maturase subunit HydE TIM beta/alpha-barrel, Radical SAM enzymes, UNMATCHED 1.7Å Yes Yes
3CIX_A (3340215) [FeFe] hydrogenase maturase subunit HydE UNMATCHED, UNMATCHED, UNMATCHED 3CIX 1.7Å No No
3IIX_A (3470979) [FeFe] hydrogenase maturase subunit HydE TIM beta/alpha-barrel, Radical SAM enzymes, UNMATCHED 1.25Å Yes Yes
3IIX_A (3470980) [FeFe] hydrogenase maturase subunit HydE UNMATCHED, UNMATCHED, UNMATCHED 3IIX 1.25Å No No
3IIZ_A (3470981) [FeFe] hydrogenase maturase subunit HydE TIM beta/alpha-barrel, Radical SAM enzymes, UNMATCHED 1.62Å Yes Yes
3IIZ_A (3470982) [FeFe] hydrogenase maturase subunit HydE UNMATCHED, UNMATCHED, UNMATCHED 3IIZ 1.62Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score