Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q9X0Z6) - Overview - Molecular Target Synopsis

Protein


, [FeFe] hydrogenase maturase subunit HydE
Enzyme Classification 1.8.-.-
UniProt Q9X0Z6

Also Known as HYDE_THEMA

Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster (PubMed:16137685). Monomer.

5FEX
HYDE FROM T. MARITIMA IN COMPLEX WITH SE-ADENOSYL-L-SELENOCYSTEINE (TFINAL OF THE REACTION)
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
348Q9X0Z6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
19 structures (19 chains) solved
19 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

is solved in complex with the approved drug(s):

MET/METHIONINE (3IIX_A, 5FEW_A, 5FEX_A, 5FEZ_A, 5FF0_A).

(see details)
Molecular Target 3D Synopsis