Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fliM (Q9WZE6) - Overview - Molecular Target Synopsis

Protein


fliM, Flagellar motor switch protein FliM
UniProt Q9WZE6

Also Known as FLIM_THEMA, fliM

FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheX chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Interacts (via N-terminus) with unphosphorylated CheY. Interacts (via central domain) with FliG (via central domain or via central domain and C-terminus).

4QRM
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF FLIM-FLIG MIDDLE DOMAINS FROM T.MARITIMA
RCSB/PDB
Inspect Structure
See all 3D Structures for fliM

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
328Q9WZE6-1

Sub-cellular localization


UniProt: fliM is active in the following subcellular-locations: bacterial flagellum basal body, cell inner membrane.
GO terms: fliM is active in the following subcellular-locations: bacterial-type flagellum basal body, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project fliM has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fliM there are:
5 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis