Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

cobB (Q9WYW0) - Overview - Molecular Target Synopsis


cobB, NAD-dependent protein deacetylase
Enzyme Classification 3.5.1.-
UniProt Q9WYW0

Also Known as NPD_THEMA, cobB, sir2

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: cobB is active in the following subcellular-locations: cytoplasm.
GO terms: cobB is active in the following subcellular-locations: cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project cobB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For cobB there are:
16 structures (18 chains) solved
9 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

cobB has been screened with 1 compounds (1 bioactivities). (see details)