Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

cobB (Q9WYW0) - Overview - Molecular Target Synopsis

Protein


cobB, NAD-dependent protein deacetylase
Enzyme Classification 3.5.1.-
UniProt Q9WYW0

Also Known as NPD_THEMA, cobB, sir2

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
246Q9WYW0-1

Sub-cellular localization


UniProt: cobB is active in the following subcellular-locations: cytoplasm.
GO terms: cobB is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project cobB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cobB there are:
16 structures (18 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


cobB has been screened with 1 compounds (1 bioactivities). (see details)