Molecular Target Synopsis
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fliG (Q9WY63) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria5
Chains with at least one site assessed as druggable using the relaxed criteria17


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4QRM_N Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 73.4 26.6 Yes No
2 empty 2.21 68.4 14 No No
3 empty 1.08 68.2 11.4 No No
4 empty 2.67 56.2 10.2 No No
5 empty 2.18 62.6 7.2 No No
6 empty 2.86 48.3 8.4 No No
7 empty 2.55 69.2 7 No No
8 empty 2.65 76.1 0 No No
9 empty 3.23 68.6 5.4 No No
10 empty 1.97 70.7 0 No No
5TDY_D Flagellar motor switch protein FliG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 62.4 22.6 No No
2 empty 1.89 62.4 28.7 No No
3 empty .94 63.1 10.1 No No
4 empty 1.66 22.5 10.6 No No
5 empty 2.09 53.1 7.6 No No
6 empty 1.92 54.4 8.4 No No
7 empty 1.91 51.8 7.9 No No
8 empty 2.48 55 8 No No
9 empty 1.97 59.6 7.3 No No
10 empty 2.15 62.8 8.6 No No
3SOH_D Flagellar motor switch protein FliG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.48 76.8 21.7 Yes Yes
2 empty 2.24 68.7 15.1 No No
3 empty 1.33 63.1 12.1 No No
4 empty 2 65.5 9.5 No No
5 empty 2.21 61.1 12.6 No No
6 empty 2.59 77.4 7.5 No No
7 empty 2.35 63.2 6.5 No No
8 empty 2.51 66.7 5.6 No No
9 empty 2.18 69.1 5.4 No No
10 empty 3.14 73.8 5.7 No No
4QRM_B Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 73.6 18.3 Yes No
2 empty 2.26 67.4 19.2 No No
3 empty 1.35 65.1 10.1 No No
4 empty 2.16 63.4 11 No No
5 empty 2.34 60.7 15.7 No No
6 empty 2 56.9 11.2 No No
7 empty 3.23 69.3 5.3 No No
8 empty 2.23 57.7 6.5 No No
9 empty 2.51 74 0 No No
10 empty 2.72 75.4 6.2 No No
4QRM_V Flagellar motor switch protein FliG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 76.1 18.4 Yes Yes
2 empty 2.47 65.6 15.3 No No
3 empty 1.1 58.4 13 No No
4 empty 2.82 66.7 12.7 No No
5 empty 2.93 63.4 8.8 No No
6 empty 2.42 64.8 10 No No
7 empty 2.21 69.7 7.4 No No
8 empty 2.73 55 8.6 No No
9 empty 2.62 61.5 5.4 No No
10 empty 2.58 72.9 5.4 No No
4QRM_D Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 75.7 17.3 Yes No
2 empty 2.16 68 23.5 No No
3 empty 1.03 63.2 10.4 No No
4 empty 2.3 64.6 11 No No
5 empty 2.19 60.1 9.2 No No
6 empty 2.94 62 6.4 No No
7 empty 2.11 63.9 7.8 No No
8 empty 2.07 58.8 7.7 No No
9 empty 3.1 66.3 6.4 No No
10 empty 3.16 69.9 0 No No
4QRM_H Flagellar motor switch protein FliG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 69.4 34.2 Yes Yes
2 empty .99 62.5 11.2 No No
3 empty 2.96 65.2 11.7 No No
4 empty 2.34 64.3 10.9 No No
5 empty 2.2 67.8 9.7 No No
6 empty 2.61 57.4 8.2 No No
7 empty 3.21 65.3 5.1 No No
8 empty 2.49 69.1 4.4 No No
9 empty 2.87 61.3 5.7 No No
10 empty 1.29 60.9 5.9 No No
4FHR_B Flagellar motor switch protein FliG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 73.9 29 Yes Yes
2 empty 2.2 65.7 22.6 No No
3 empty 2.26 61.9 19.4 No No
4 empty 2.24 63.9 16 No No
5 empty 2.26 66.6 17 No No
6 empty 2.38 63.3 9.7 No No
7 empty 2.18 56.4 16.7 No No
8 empty 2.7 63.2 13.1 No No
9 empty 2.91 61.7 13.9 No No
10 empty 2.05 61.9 9.2 No No
4QRM_F Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 66.7 35.7 Yes No
2 empty 1.57 75.5 21.1 Yes No
3 empty 1.19 62.1 12.9 No No
4 empty 2.04 60.7 10.9 No No
5 empty 2.63 72.5 6.1 No No
6 empty 2.16 67.7 4.6 No No
7 empty 1.97 67.4 5.1 No No
8 empty 2.7 78.5 0 No No
4QRM_P Flagellar motor switch protein FliG Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 72 23.2 Yes Yes
2 empty 2.04 69.4 16.1 No No
3 empty 1.17 63.5 15.4 No No
4 empty 2.55 65.3 10 No No
5 empty 2.69 74.6 6.7 No No
6 empty 2.5 65.2 7.3 No No
7 empty 2.85 64 6.3 No No
8 empty 2.44 45.9 6.5 No No
9 empty 2.24 66.1 5.6 No No
10 empty 2.24 67.4 6.6 No No
5TDY_B Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 61.3 27.8 Yes No
2 empty 1.75 60 29 No No
3 empty 1.71 59.9 16.3 No No
4 empty 1.2 59 14.6 No No
5 empty 2.53 74.6 9.1 No No
6 empty 1.96 60.6 11 No No
7 empty 2.61 68.9 9.9 No No
8 empty 2.11 62.7 11.4 No No
9 empty 2.69 51.7 8.1 No No
10 empty 2.34 56.5 6.5 No No
3AJC_A Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 64 34.7 Yes No
2 empty 2.41 61.9 35.4 No No
3 empty 2.32 65.4 22.7 No No
4 empty 2.24 69.8 18.1 No No
5 empty 1.49 67.9 12.1 No No
6 empty 2.16 66.4 13.6 No No
7 empty 2.4 67.2 10.6 No No
8 empty 2.32 65.9 12.3 No No
9 empty 2.3 63.8 9.8 No No
10 empty 2.47 66.5 8.3 No No
4QRM_R Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 71.9 19.4 Yes No
2 empty 2.41 65.3 28.1 No No
3 empty 1.34 64.9 13.4 No No
4 empty 2.53 66.1 13 No No
5 empty 2.08 63.6 11.3 No No
6 empty 2.63 60.6 11 No No
7 empty 2.94 53.5 11.4 No No
8 empty 2.96 58.2 6.4 No No
9 empty 2.71 63 6.5 No No
10 empty 2.36 69.2 5.2 No No
1LKV_X Flagellar motor switch protein FliG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 64.5 23.3 No No
2 empty 2.24 65.2 21.5 No No
3 empty 1.87 49 19.5 No No
4 empty 2.21 63.6 21.8 No No
5 empty 2.21 64.6 22.8 No No
6 empty 1.15 57.3 15.5 No No
7 empty 2.11 66.3 14.8 No No
8 empty 2.44 62 12.3 No No
9 empty 2.53 69.4 9.3 No No
10 empty 2.15 55.7 13.7 No No
4QRM_L Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 74.4 19.2 Yes No
2 empty 2.13 67.3 15 No No
3 empty 1.21 62.9 14.2 No No
4 empty 2.47 66.5 9.8 No No
5 empty 2.52 71.4 6.8 No No
6 empty 2.38 65.6 7.7 No No
7 empty 2.68 71.3 5.3 No No
8 empty 2.34 71.3 6.9 No No
9 empty 2.83 67.8 5.4 No No
10 empty 2.48 63.9 5.1 No No
3SOH_B Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 68.9 24.1 Yes No
2 empty 2.29 67.6 20.3 No No
3 empty 1.36 58.9 13.3 No No
4 empty 2.03 65.6 10 No No
5 empty 2.44 68.9 8.6 No No
6 empty 2.2 64.8 8.1 No No
7 empty 2.66 74.8 7.1 No No
8 empty 2.69 56.8 6.1 No No
9 empty 3.06 67 6.9 No No
10 empty 2.98 64.5 5 No No
1QC7_B Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 62.3 40.3 Yes No
2 empty 1.96 66.1 15.3 No No
3 empty 1.58 49.5 14.9 No No
4 empty 2.02 60.8 11.8 No No
5 empty 2.31 57.1 10 No No
6 empty 2.16 58.8 10.8 No No
7 empty .68 98.5 0 Yes No
8 empty 2.53 65 7 No No
9 empty 2.52 53.9 8.3 No No
10 empty 3 67.3 6.3 No No
1QC7_A Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 58.5 36.8 Yes No
2 empty 1.96 62.6 21.5 No No
3 empty 2.61 62.9 19.5 No No
4 empty 2.49 60.9 9.1 No No
5 empty 2.5 45.7 10 No No
6 empty 2.34 60.1 8.4 No No
7 empty .82 94.3 0 Yes No
8 empty 2.5 61.4 5.6 No No
9 empty 3.02 55.8 5.9 No No
10 empty 2.76 51.4 6.6 No No
4QRM_J Flagellar motor switch protein FliG No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 69 17.3 No No
2 empty 1.04 62 12.8 No No
3 empty 1.94 65.4 10.6 No No
4 empty 1.91 63.2 12.2 No No
5 empty 2.33 63.5 7.2 No No
6 empty 2.76 79.5 0 No No
7 empty 2.88 56 8.4 No No
8 empty 2.6 51 7.6 No No
9 empty 2.61 51.6 6.1 No No
10 empty 1.97 59.7 7.6 No No
4QRM_T Flagellar motor switch protein FliG Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 74.7 21.8 Yes No
2 empty 2.38 67.3 22.1 No No
3 empty 1.36 62 13.1 No No
4 empty 2.39 83.4 11.2 No No
5 empty 2.78 62.6 9.9 No No
6 empty 2.69 61.3 9.5 No No
7 empty 2 71 5.2 No No
8 empty 2.41 66.3 5.8 No No
9 empty 2.74 66.3 5.7 No No
10 empty .34 98.3 0 Yes No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1LKV_X (73980) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG 2.798Å No No
1QC7_A (18456) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG 2.2Å Yes No
1QC7_B (18457) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG 2.2Å Yes No
1QC7_B (4227020) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG (Homo Multimer) 2.2Å Yes Yes
1QC7_A (4227020) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG (Homo Multimer) 2.2Å Yes Yes
3AJC_A (4252746) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, FliG 2.3Å Yes No
3SOH_B (3710373) Flagellar motor switch protein FliG alpha-alpha superhelix, FliG, UNMATCHED 3.5Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score