Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fliG (Q9WY63) - Overview - Molecular Target Synopsis

Protein


fliG, Flagellar motor switch protein FliG
UniProt Q9WY63

Also Known as FLIG_THEMA, fliG

One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). Homodimer in the absence of FliF. Interacts (via N-terminus) with FliF (via C-terminus) forming a heterodimer. Interacts (via central domain or via central domain and C-terminus) with FliM (via central domain).

5TDY
STRUCTURE OF COFOLDED FLIFC:FLIGN COMPLEX FROM THERMOTOGA MARITIMA
RCSB/PDB
Inspect Structure
See all 3D Structures for fliG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
335Q9WY63-1

Sub-cellular localization


UniProt: fliG is active in the following subcellular-locations: bacterial flagellum basal body, cell inner membrane.
GO terms: fliG is active in the following subcellular-locations: bacterial-type flagellum basal body, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project fliG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fliG there are:
7 structures (20 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis