Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Map2k5 (Q9WVS7) - Overview - Molecular Target Synopsis

Protein


Map2k5, Dual specificity mitogen-activated protein kinase kinase 5
Enzyme Classification 2.7.12.2
UniProt Q9WVS7

Also Known as MP2K5_MOUSE, Map2k5, Mek5, Mkk5, Prkmk5

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI.

1WI0
SOLUTION STRUCTURE OF THE PB1 DOMAIN OF MOUSE MITOGEN ACTIVATED PROTEIN KINASE KINASE 5 (MAP2K5)
RCSB/PDB
Inspect Structure
See all 3D Structures for Map2k5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
448Q9WVS7-1
439Q9WVS7-2
186Q9WVS7-3
118Q9WVS7-4

Sub-cellular localization


UniProt: Map2k5 is active in the following subcellular-locations: cytoplasm.
GO terms: Map2k5 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Map2k5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Map2k5 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Map2k5 has been screened with compounds ( bioactivities). (see details)