Map2k5, Dual specificity mitogen-activated protein kinase kinase 5
Enzyme Classification 184.108.40.206
Also Known as
MP2K5_MOUSE, Map2k5, Mek5, Mkk5, Prkmk5
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI.