Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

lid (Q9VMJ7) - Overview - Molecular Target Synopsis

Protein


lid, Lysine-specific demethylase lid
Enzyme Classification 1.14.11.-
UniProt Q9VMJ7

Also Known as KDM5_DROME, lid

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry. Interacts with Myc. Part of a complex containing Lid, Myc and Ash2.

2MIQ
SOLUTION NMR STRUCTURE OF PHD TYPE 1 ZINC FINGER DOMAIN 1 OF LYSINE- SPECIFIC DEMETHYLASE LID FROM DROSOPHILA MELANOGASTER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET FR824J
RCSB/PDB
Inspect Structure
See all 3D Structures for lid

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1838Q9VMJ7-1

Sub-cellular localization


UniProt: lid is active in the following subcellular-locations: nucleus.
GO terms: lid is active in the following subcellular-locations: histone methyltransferase complex, nucleus, Sin3-type complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project lid has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For lid there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


lid has been screened with compounds ( bioactivities). (see details)