TppII (Q9V6K1) - Overview - Molecular Target Synopsis
TppII, Tripeptidyl-peptidase 2
Enzyme Classification 220.127.116.11
Also Known as TPP2_DROME, TppII
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide. Homooligomer; forms a complex of 6 MDa probably composed of 40 subunits. Forms a structure consisting of 2 segmented and twisted strands that form a spindle-shaped structure. Each strand is composed of 10 segments (a segment being a homodimer oriented head to head), stacking of these segments leads to the formation of a twisted single strand. 2 strands compose the fully assembled spindle.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: TppII is active in the following subcellular-locations: cytoplasm.
GO terms: TppII is active in the following subcellular-locations: cytosol.