Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TppII (Q9V6K1) - Overview - Molecular Target Synopsis


TppII, Tripeptidyl-peptidase 2
Enzyme Classification
UniProt Q9V6K1

Also Known as TPP2_DROME, TppII

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide. Homooligomer; forms a complex of 6 MDa probably composed of 40 subunits. Forms a structure consisting of 2 segmented and twisted strands that form a spindle-shaped structure. Each strand is composed of 10 segments (a segment being a homodimer oriented head to head), stacking of these segments leads to the formation of a twisted single strand. 2 strands compose the fully assembled spindle.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: TppII is active in the following subcellular-locations: cytoplasm.
GO terms: TppII is active in the following subcellular-locations: cytosol.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TppII has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For TppII there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TppII has been screened with compounds ( bioactivities). (see details)