Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rrp41 (Q9UXC2) - Overview - Molecular Target Synopsis

Protein


rrp41, Exosome complex component Rrp41
Enzyme Classification 3.1.13.-
UniProt Q9UXC2

Also Known as RRP41_SACS2, rrp41

Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. Binds RNA. Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.

4BA1
ARCHAEAL EXOSOME (RRP4-RRP41(D182A)-RRP42) BOUND TO INORGANIC PHOSPHATE
RCSB/PDB
Inspect Structure
See all 3D Structures for rrp41

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
248Q9UXC2-1

Sub-cellular localization


UniProt: rrp41 is active in the following subcellular-locations: cytoplasm.
GO terms: rrp41 is active in the following subcellular-locations: cytoplasmic exosome (RNase complex).



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rrp41 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rrp41 there are:
10 structures (56 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

rrp41 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2C38_B, 2C38_F, 2C38_H, 2C38_J, 2C38_N, 2C38_V, 2C38_X).

(see details)
Molecular Target 3D Synopsis