Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

gtb1 (Q9USH8) - Overview - Molecular Target Synopsis

Protein


gtb1, Glucosidase 2 subunit beta
UniProt Q9USH8

Also Known as GLU2B_SCHPO, gtb1, gls2-beta

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER. Heterodimer of a catalytic subunit alpha (gls2) and a subunit beta (gtb1).

2N1H
SOLUTION STRUCTURE OF THE GBII-BETA MRH DOMAIN W409A POINT MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for gtb1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
506Q9USH8-1

Sub-cellular localization


UniProt: gtb1 is active in the following subcellular-locations: endoplasmic reticulum.
GO terms: gtb1 is active in the following subcellular-locations: endoplasmic reticulum, glucosidase II complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project gtb1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For gtb1 there are:
3 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


gtb1 has been screened with compounds ( bioactivities). (see details)