Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAALADL1 (Q9UQQ1) - Overview - Molecular Target Synopsis

Protein


NAALADL1, N-acetylated-alpha-linked acidic dipeptidase-like protein
Enzyme Classification 3.4.17.21
UniProt Q9UQQ1

Also Known as NALDL_HUMAN, NAALADL1, NAALADASEL, NAALADL

NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

4TWE
STRUCTURE OF LIGAND-FREE N-ACETYLATED-ALPHA-LINKED-ACIDIC-DIPEPTIDASE LIKE PROTEIN (NAALADASEL)
RCSB/PDB
Inspect Structure
See all 3D Structures for NAALADL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAALADL1 is active in the following subcellular-locations: apical cell membrane.
GO terms: NAALADL1 is active in the following subcellular-locations: apical plasma membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAALADL1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SNB_75, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, SCLC-21H, SW 1463

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


For NAALADL1 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NAALADL1 has been screened with compounds ( bioactivities). (see details)