Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AURKC (Q9UQB9) - Overview - Molecular Target Synopsis


AURKC, Aurora kinase C
Enzyme Classification
UniProt Q9UQB9


Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: AURKC is active in the following subcellular-locations: centromere, chromosome, cytoplasm, cytoskeleton, nucleus, spindle.
GO terms: AURKC is active in the following subcellular-locations: chromosome passenger complex, condensed chromosome, condensed nuclear chromosome, cytoplasm, midbody, spindle, spindle microtubule, spindle midzone, spindle pole centrosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project AURKC has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HN, NTERA-2, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

AURKC was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, MCF12A. (see details)

3D Structures

At greater than 75% identity similarity to AURKC there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

AURKC has been screened with 848 compounds (1530 bioactivities), 57 compounds have bioactivities that show binding affinity of <= 500nM (96 bioactivities). (see details)