AURKC (Q9UQB9) - Overview - Molecular Target Synopsis
AURKC, Aurora kinase C
Enzyme Classification 18.104.22.168
Also Known as AURKC_HUMAN, AURKC, AIE2, AIK3, AIRK3, ARK3, STK13
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|275||ENSG00000105146||ENST00000598785, ENST00000448930||ENSP00000471830, ENSP00000406798||Q9UQB9-2|
UniProt: AURKC is active in the following subcellular-locations: centromere, chromosome, cytoplasm, cytoskeleton, nucleus, spindle.
GO terms: AURKC is active in the following subcellular-locations: chromosome passenger complex, condensed chromosome, condensed nuclear chromosome, cytoplasm, midbody, spindle, spindle microtubule, spindle midzone, spindle pole centrosome.