Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AURKC (Q9UQB9) - Overview - Molecular Target Synopsis

Protein


AURKC, Aurora kinase C
Enzyme Classification 2.7.11.1
UniProt Q9UQB9

Also Known as AURKC_HUMAN, AURKC, AIE2, AIK3, AIRK3, ARK3, STK13

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

6GR8
HUMAN AURKC INCENP COMPLEX BOUND TO BRD-7880
RCSB/PDB
Inspect Structure
See all 3D Structures for AURKC

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AURKC is active in the following subcellular-locations: centromere, chromosome, cytoplasm, cytoskeleton, nucleus, spindle.
GO terms: AURKC is active in the following subcellular-locations: chromosome passenger complex, condensed chromosome, condensed nuclear chromosome, cytoplasm, midbody, spindle, spindle microtubule, spindle midzone, spindle pole centrosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AURKC has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HN, NTERA-2, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


AURKC was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, MCF12A. (see details)

3D Structures


For AURKC there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AURKC has been screened with 865 compounds (1567 bioactivities), 60 compounds have bioactivities that show binding affinity of <= 500nM (102 bioactivities). (see details)