EXO1 (Q9UQ84) - Overview - Molecular Target Synopsis
EXO1, Exonuclease 1
Enzyme Classification 3.1.-.-
Also Known as EXO1_HUMAN, EXO1, EXOI, HEX1
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|846||ENSG00000174371||ENST00000348581, ENST00000366548||ENSP00000311873, ENSP00000355506||Q9UQ84-1|
UniProt: EXO1 is active in the following subcellular-locations: nucleus.
GO terms: EXO1 is active in the following subcellular-locations: nuclear body, nucleoplasm, nucleus, plasma membrane.