Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MOK (Q9UQ07) - Overview - Molecular Target Synopsis

Protein


MOK, MAPK/MAK/MRK overlapping kinase
Enzyme Classification 2.7.11.22
UniProt Q9UQ07

Also Known as MOK_HUMAN, MOK, RAGE, RAGE1

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MOK is active in the following subcellular-locations: cell projection, cilium, cytoplasm, nucleus.
GO terms: MOK is active in the following subcellular-locations: ciliary base, cilium, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MOK has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2373, NCI-H2052, RERF-LC-OK

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

RNA Interference


MOK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: ASPC1, AC295. (see details)

3D Structures


At greater than 35% identity similarity to MOK there are:
12 structures (21 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MOK has been screened with compounds ( bioactivities). (see details)