Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ICK (Q9UPZ9) - Overview - Molecular Target Synopsis

Protein


ICK, Serine/threonine-protein kinase ICK
Enzyme Classification 2.7.11.1
UniProt Q9UPZ9

Also Known as ICK_HUMAN, ICK, KIAA0936

Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
632ENSG00000112144ENST00000350082, ENST00000356971ENSP00000263043, ENSP00000349458Q9UPZ9-1
292Q9UPZ9-2

Sub-cellular localization


UniProt: ICK is active in the following subcellular-locations: cell projection, cilium, cilium basal body, cytoplasm, cytoskeleton, cytosol, nucleus.
GO terms: ICK is active in the following subcellular-locations: ciliary basal body, ciliary base, ciliary tip, cilium, cytoplasm, cytosol, fibrillar center, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ICK has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HS578T, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H520, UCSD-242l, COLO 205

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, SK-N-SH

(see details)

RNA Interference


ICK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SCC90, HUO3N1. (see details)

3D Structures


At greater than 35% identity similarity to ICK there are:
182 structures (250 chains) solved
169 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ICK has been screened with 91 compounds (97 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (11 bioactivities). (see details)