Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAPRE3 (Q9UPY8) - Overview - Molecular Target Synopsis

Protein


MAPRE3, Microtubule-associated protein RP/EB family member 3
UniProt Q9UPY8

Also Known as MARE3_HUMAN, MAPRE3

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration. Interacts with APC2 (PubMed:10644998). Homodimer (PubMed:19255245). Heterodimer with MAPRE1 (PubMed:19255245). Interacts with DCTN1 and SRCIN1 (PubMed:14514668, PubMed:19146815). Binds to the C-terminal domain of APC (PubMed:14514668). Binds monomeric and polymerized tubulin (PubMed:10188731). Interacts (via C-terminus) with CLIP1 (PubMed:17563362). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with AKAP9 (PubMed:28814570). Interacts with PDE4DIP (PubMed:28814570). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (PubMed:25217626).

3JAL
CRYO-EM STRUCTURE OF GMPCPP-MICROTUBULE CO-POLYMERIZED WITH EB3
RCSB/PDB
Inspect Structure
See all 3D Structures for MAPRE3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAPRE3 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: MAPRE3 is active in the following subcellular-locations: cytoplasm, cytoplasmic microtubule, microtubule, microtubule cytoskeleton, microtubule organizing center, microtubule plus-end, midbody, perinuclear region of cytoplasm, spindle midzone.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAPRE3 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_295, A498, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1623, HCC12, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HSMM

(see details)

3D Structures


For MAPRE3 there are:
6 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis