Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A11 (Q9UPY5) - Overview - Molecular Target Synopsis

Protein


SLC7A11, Cystine/glutamate transporter
UniProt Q9UPY5

Also Known as XCT_HUMAN, SLC7A11

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
501ENSG00000151012ENST00000280612ENSP00000280612Q9UPY5-1
75ENSG00000151012ENST00000509248ENSP00000424046

Sub-cellular localization


UniProt: SLC7A11 is active in the following subcellular-locations: membrane.
GO terms: SLC7A11 is active in the following subcellular-locations: astrocyte projection, brush border membrane, cell surface, cytoskeleton, integral component of membrane, plasma membrane, rough endoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A11 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, SF_295, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MES-1, Hs 746T, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, BJ, HeLa-S3

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A11 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A11 has been screened with 110 compounds (141 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (11 bioactivities). (see details)