Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCAF8 (Q9UPN6) - Overview - Molecular Target Synopsis

Protein


SCAF8, Protein SCAF8
UniProt Q9UPN6

Also Known as SCAF8_HUMAN, SCAF8, CCAP7, KIAA1116, RBM16

May play a role in mRNA processing. Interacts with POLR2A (via C-terminus). Has much higher affinity for phosphorylated POLR2A. Identified in a complex with CDC5L and other spliceosomal proteins. May associate with the spliceosome.

3D9I
SNAPSHOTS OF THE RNA PROCESSING FACTOR SCAF8 BOUND TO DIFFERENT PHOSPHORYLATED FORMS OF THE CARBOXY-TERMINAL DOMAIN OF RNA-POLYMERASE II
RCSB/PDB
Inspect Structure
See all 3D Structures for SCAF8

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1337ENSG00000213079ENST00000367186ENSP00000356154Q9UPN6-2
1271ENSG00000213079ENST00000367178, ENST00000417268ENSP00000356146, ENSP00000413098Q9UPN6-1

Sub-cellular localization


UniProt: SCAF8 is active in the following subcellular-locations: nucleus, nucleus matrix.
GO terms: SCAF8 is active in the following subcellular-locations: cytoplasm, nuclear matrix, nucleoplasm, spliceosomal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCAF8 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HEL, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, SK-N-SH

(see details)

3D Structures


For SCAF8 there are:
9 structures (17 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis