Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FLVCR2 (Q9UPI3) - Overview - Molecular Target Synopsis

Protein


FLVCR2, Feline leukemia virus subgroup C receptor-related protein 2
UniProt Q9UPI3

Also Known as FLVC2_HUMAN, FLVCR2, C14orf58

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FLVCR2 is active in the following subcellular-locations: cell membrane.
GO terms: FLVCR2 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FLVCR2 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, MDA_MB_231, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RERF-LC-KJ, SUM 159PT, NCI-H1568

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, MCF-7, SK-N-SH

(see details)