Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SRPK3 (Q9UPE1) - Overview - Molecular Target Synopsis

Protein


SRPK3, SRSF protein kinase 3
Enzyme Classification 2.7.11.1
UniProt Q9UPE1

Also Known as SRPK3_HUMAN, SRPK3, MSSK1, STK23

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: SRPK3 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SRPK3 has gain in 1 cell-lines, loss in 18 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, CAKI_1, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SJCRH30, LXFL529, KMS-21BM

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

RNA Interference


SRPK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HUO9, SMOV2. (see details)

3D Structures


At greater than 75% identity similarity to SRPK3 there are:
9 structures (12 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SRPK3 is solved in complex with the approved drug(s):

EMH/ALECTINIB (5XV7_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SRPK3 has been screened with 651 compounds (1203 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (14 bioactivities). (see details)