Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFR2 (Q9UP52) - Overview - Molecular Target Synopsis

Protein


TFR2, Transferrin receptor protein 2
UniProt Q9UP52

Also Known as TFR2_HUMAN, TFR2

Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TFR2 is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: TFR2 is active in the following subcellular-locations: cytoplasmic vesicle, external side of plasma membrane, HFE-transferrin receptor complex, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFR2 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, SR, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M1, HEL, MOLM-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to TFR2 there are:
11 structures (28 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TFR2 has been screened with compounds ( bioactivities). (see details)