Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MINPP1 (Q9UNW1) - Overview - Molecular Target Synopsis

Protein


MINPP1, Multiple inositol polyphosphate phosphatase 1
Enzyme Classification 3.1.3.62
UniProt Q9UNW1

Also Known as MINP1_HUMAN, MINPP1, MIPP

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MINPP1 is active in the following subcellular-locations: endoplasmic reticulum lumen.
GO terms: MINPP1 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MINPP1 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MDA_N, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KU812, Hs 675.T, MOLM-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, A549

(see details)