Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RABL2B (Q9UNT1) - Overview - Molecular Target Synopsis

Protein


RABL2B, Rab-like protein 2B
UniProt Q9UNT1

Also Known as RBL2B_HUMAN, RABL2B

Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565). Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Interacts (in its GTP-bound form) with CEP19 (via residues 121-150); this interaction is required for its localization to the mother centriole and cilium basal body. Interacts (in its GTP-bound form) with the intraflagellar transport (IFT) complex B (via the IFT74-IFT81 heterodimer) (PubMed:28625565, PubMed:28428259). Binding to CEP19 and the IFT74-IFT81 heterodimer is mutually exclusive (PubMed:28428259).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RABL2B is active in the following subcellular-locations: centriole, centrosome, cilium basal body, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: RABL2B is active in the following subcellular-locations: centriole, ciliary basal body, cytoplasm, pericentriolar material.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RABL2B has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, COLO205, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1162, SK-N-FI, NCI-H345

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to RABL2B there are:
55 structures (121 chains) solved
51 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RABL2B is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RABL2B has been screened with compounds ( bioactivities). (see details)