RABL2B (Q9UNT1) - Overview - Molecular Target Synopsis
RABL2B, Rab-like protein 2B
Also Known as RBL2B_HUMAN, RABL2B
Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565). Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Interacts (in its GTP-bound form) with CEP19 (via residues 121-150); this interaction is required for its localization to the mother centriole and cilium basal body. Interacts (in its GTP-bound form) with the intraflagellar transport (IFT) complex B (via the IFT74-IFT81 heterodimer) (PubMed:28625565, PubMed:28428259). Binding to CEP19 and the IFT74-IFT81 heterodimer is mutually exclusive (PubMed:28428259).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|229||ENSG00000079974||ENST00000354869, ENST00000395595||ENSP00000346940, ENSP00000378960||Q9UNT1-2|
|228||ENSG00000079974||ENST00000435118, ENST00000395598||ENSP00000401906, ENSP00000378962||Q9UNT1-1|
UniProt: RABL2B is active in the following subcellular-locations: centriole, centrosome, cilium basal body, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: RABL2B is active in the following subcellular-locations: centriole, ciliary basal body, cytoplasm, pericentriolar material.