Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DIMT1 (Q9UNQ2) - Overview - Molecular Target Synopsis

Protein


DIMT1, Probable dimethyladenosine transferase
Enzyme Classification 2.1.1.183
UniProt Q9UNQ2

Also Known as DIM1_HUMAN, DIMT1, DIMT1L

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604).

1ZQ9
CRYSTAL STRUCTURE OF HUMAN DIMETHYLADENOSINE TRANSFERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for DIMT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DIMT1 is active in the following subcellular-locations: nucleolus, nucleoplasm, nucleus.
GO terms: DIMT1 is active in the following subcellular-locations: cytosol, mitochondrial matrix, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DIMT1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, MHH-PREB-1, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For DIMT1 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis