POLI (Q9UNA4) - Overview - Molecular Target Synopsis
POLI, DNA polymerase iota
Enzyme Classification 188.8.131.52
Also Known as POLI_HUMAN, POLI, RAD30B
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. Interacts with REV1 (By similarity). Interacts with POLH.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: POLI is active in the following subcellular-locations: nucleus.
GO terms: POLI is active in the following subcellular-locations: cytoplasmic ribonucleoprotein granule, intracellular, nuclear speck, nucleoplasm.