Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A7 (Q9UM01) - Overview - Molecular Target Synopsis


SLC7A7, Y+L amino acid transporter 1
UniProt Q9UM01

Also Known as YLAT1_HUMAN, SLC7A7

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SLC7A7 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLC7A7 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A7 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A549, HCT_15, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H226, OV-90, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, CD14-positive monocyte, GM12878

(see details)

3D Structures

At greater than 35% identity similarity to SLC7A7 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A7 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A7 has been screened with compounds ( bioactivities). (see details)