Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A7 (Q9UM01) - Overview - Molecular Target Synopsis

Protein


SLC7A7, Y+L amino acid transporter 1
UniProt Q9UM01

Also Known as YLAT1_HUMAN, SLC7A7

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC7A7 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLC7A7 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A7 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, HCT_15, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H226, OV-90, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, CD14-positive monocyte, GM12878

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A7 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A7 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6JMQ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A7 has been screened with compounds ( bioactivities). (see details)