Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CA14 (Q9ULX7) - Overview - Molecular Target Synopsis

Protein


CA14, Carbonic anhydrase 14
Enzyme Classification 4.2.1.1
UniProt Q9ULX7

Also Known as CAH14_HUMAN, CA14

Reversible hydration of carbon dioxide.

5CJF
THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE XIV IN COMPLEX WITH A 1,1'-BIPHENYL-4-SULFONAMIDE INHIBITOR.
RCSB/PDB
Inspect Structure
See all 3D Structures for CA14

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CA14 is active in the following subcellular-locations: membrane.
GO terms: CA14 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CA14 has gain in 17 cell-lines, loss in 0 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, MDA_N, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NTERA-2, UACC-257, MeWo

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For CA14 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CA14 is solved in complex with the approved drug(s):

AZM/ACETAZOLAMIDE (4LU3_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CA14 has been screened with 814 compounds (1061 bioactivities), 400 compounds have bioactivities that show binding affinity of <= 500nM (548 bioactivities). (see details)