Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB26 (Q9ULW5) - Overview - Molecular Target Synopsis

Protein


RAB26, Ras-related protein Rab-26
UniProt Q9ULW5

Also Known as RAB26_HUMAN, RAB26

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. Interacts with RIMS1 (By similarity). Interacts with ADRA2B.

2G6B
CRYSTAL STRUCTURE OF HUMAN RAB26 IN COMPLEX WITH A GTP ANALOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB26

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB26 is active in the following subcellular-locations: cytoplasmic vesicle, golgi apparatus membrane, secretory vesicle membrane.
GO terms: RAB26 is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, Golgi membrane, intrinsic component of plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB26 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, T47D, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H716, NCI-H146, RERF-LC-KJ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)

3D Structures


For RAB26 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB26 has been screened with compounds ( bioactivities). (see details)