Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSL5 (Q9ULC5) - Overview - Molecular Target Synopsis

Protein


ACSL5, Long-chain-fatty-acid--CoA ligase 5
Enzyme Classification 6.2.1.3
UniProt Q9ULC5

Also Known as ACSL5_HUMAN, ACSL5, ACS5, FACL5

Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSL5 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrion, mitochondrion outer membrane.
GO terms: ACSL5 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSL5 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HT29, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, SNU-719, SNU-C1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, HSMM

(see details)


Screening and Chemistry


ACSL5 has been screened with compounds ( bioactivities). (see details)