ACSL5 (Q9ULC5) - Overview - Molecular Target Synopsis
ACSL5, Long-chain-fatty-acid--CoA ligase 5
Enzyme Classification 22.214.171.124
Also Known as ACSL5_HUMAN, ACSL5, ACS5, FACL5
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|683||ENSG00000197142||ENST00000354655, ENST00000393081, ENST00000354273||ENSP00000346680, ENSP00000376796, ENSP00000346223||Q9ULC5-1|
UniProt: ACSL5 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrion, mitochondrion outer membrane.
GO terms: ACSL5 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleolus, nucleus.