Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB23 (Q9ULC3) - Overview - Molecular Target Synopsis

Protein


RAB23, Ras-related protein Rab-23
UniProt Q9ULC3

Also Known as RAB23_HUMAN, RAB23

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. Interacts with SUFU.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
237ENSG00000112210ENST00000317483, ENST00000468148ENSP00000320413, ENSP00000417610Q9ULC3-1

Sub-cellular localization


UniProt: RAB23 is active in the following subcellular-locations: autophagosome, cell membrane, cytoplasm, cytoplasmic vesicle, endosome membrane, phagosome, phagosome membrane.
GO terms: RAB23 is active in the following subcellular-locations: autophagosome, cell junction, centrosome, cytoplasm, cytosol, endosome membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB23 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, MDA_MB_231, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, G130, Hs 578T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HFDPC

(see details)

3D Structures


At greater than 90% identity similarity to RAB23 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB23 has been screened with compounds ( bioactivities). (see details)