Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPC5 (Q9UL62) - Overview - Molecular Target Synopsis

Protein


TRPC5, Short transient receptor potential channel 5
UniProt Q9UL62

Also Known as TRPC5_HUMAN, TRPC5, TRP5

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
973ENSG00000072315ENST00000262839ENSP00000262839Q9UL62-1

Sub-cellular localization


UniProt: TRPC5 is active in the following subcellular-locations: cell membrane.
GO terms: TRPC5 is active in the following subcellular-locations: calcium channel complex, cation channel complex, cytoplasm, dendrite, growth cone, integral component of plasma membrane, membrane raft, neuronal cell body, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPC5 has gain in 0 cell-lines, loss in 34 cell-lines and no signal in 971 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, TK_10, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, NCI-H209, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to TRPC5 there are:
2 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPC5 has been screened with 10 compounds (22 bioactivities). (see details)