Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB22A (Q9UL26) - Overview - Molecular Target Synopsis

Protein


RAB22A, Ras-related protein Rab-22A
UniProt Q9UL26

Also Known as RB22A_HUMAN, RAB22A, RAB22

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
194ENSG00000124209ENST00000244040ENSP00000244040Q9UL26-1

Sub-cellular localization


UniProt: RAB22A is active in the following subcellular-locations: cell membrane, cell projection, cytoplasmic vesicle, early endosome, endosome membrane, late endosome, phagosome, phagosome membrane, ruffle.
GO terms: RAB22A is active in the following subcellular-locations: actin cytoskeleton, early endosome, endosome membrane, extracellular exosome, late endosome, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, ruffle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB22A has gain in 13 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, HT29, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-55, Hs 695T, HCC1954

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to RAB22A there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB22A has been screened with compounds ( bioactivities). (see details)