Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB22A (Q9UL26) - Overview - Molecular Target Synopsis


RAB22A, Ras-related protein Rab-22A
UniProt Q9UL26

Also Known as RB22A_HUMAN, RAB22A, RAB22

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB22A is active in the following subcellular-locations: cell membrane, cell projection, cytoplasmic vesicle, early endosome, endosome membrane, late endosome, phagosome, phagosome membrane, ruffle.
GO terms: RAB22A is active in the following subcellular-locations: actin cytoskeleton, early endosome, endosome membrane, extracellular exosome, late endosome, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, ruffle.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB22A has gain in 13 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SR, HT29, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-55, Hs 695T, HCC1954

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, HSMM

(see details)

3D Structures

At greater than 90% identity similarity to RAB22A there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB22A has been screened with compounds ( bioactivities). (see details)