Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB21 (Q9UL25) - Overview - Molecular Target Synopsis

Protein


RAB21, Ras-related protein Rab-21
UniProt Q9UL25

Also Known as RAB21_HUMAN, RAB21, KIAA0118

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain) (PubMed:17450153). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474). Interacts with VAMP7 (PubMed:25648148). Interacts (in GTP-bound form) with VAMP8 in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking (PubMed:25648148).

2OT3
CRYSTAL STRUCTURE OF RABEX-5 VPS9 DOMAIN IN COMPLEX WITH NUCLEOTIDE FREE RAB21
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB21

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
225ENSG00000080371ENST00000261263ENSP00000261263Q9UL25-1

Sub-cellular localization


UniProt: RAB21 is active in the following subcellular-locations: cleavage furrow, cytoplasmic vesicle membrane, early endosome membrane, endoplasmic reticulum membrane, golgi apparatus, golgi apparatus membrane, trans-golgi network.
GO terms: RAB21 is active in the following subcellular-locations: axon cytoplasm, cleavage furrow, cytoplasmic side of early endosome membrane, cytoplasmic side of plasma membrane, cytoplasmic vesicle membrane, cytosol, early endosome, early endosome membrane, endoplasmic reticulum membrane, endosome, extracellular exosome, focal adhesion, Golgi cisterna membrane, synapse, trans-Golgi network, vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB21 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_4, UO_31, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, HCC1143, QGP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, HMEC

(see details)

3D Structures


For RAB21 there are:
5 structures (10 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB21 has been screened with compounds ( bioactivities). (see details)