Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AGO1 (Q9UL18) - Overview - Molecular Target Synopsis

Protein


AGO1, Protein argonaute-1
UniProt Q9UL18

Also Known as AGO1_HUMAN, AGO1, EIF2C1

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.

5W6V
THE STRUCTURE OF HUMAN ARGONAUTE-1 IN COMPLEX WITH THE HOOK MOTIF OF HUMAN GW182
RCSB/PDB
Inspect Structure
See all 3D Structures for AGO1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
857ENSG00000092847ENST00000373204ENSP00000362300Q8CJG1-1, Q9UL18-1
782ENSG00000092847ENST00000373206ENSP00000362302

Sub-cellular localization


UniProt: AGO1 is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: AGO1 is active in the following subcellular-locations: cytoplasm, cytosol, micro-ribonucleoprotein complex, nucleoplasm, nucleus, P-body, polysome, ribonucleoprotein complex, RISC complex, RISC-loading complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AGO1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NTERA-2, NCI-H209, A3/KAW

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HSMM, NHLF

(see details)

3D Structures


For AGO1 there are:
6 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis