Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSL6 (Q9UKU0) - Overview - Molecular Target Synopsis

Protein


ACSL6, Long-chain-fatty-acid--CoA ligase 6
Enzyme Classification 6.2.1.3
UniProt Q9UKU0

Also Known as ACSL6_HUMAN, ACSL6, ACS2, FACL6, KIAA0837, LACS5

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSL6 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane, mitochondrion outer membrane, peroxisome membrane.
GO terms: ACSL6 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, membrane, mitochondrial outer membrane, peroxisomal membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSL6 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, HL_60, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-55, DU4475, SW 1463

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


ACSL6 has been screened with compounds ( bioactivities). (see details)