TLK1 (Q9UKI8) - Overview - Molecular Target Synopsis
TLK1, Serine/threonine-protein kinase tousled-like 1
Enzyme Classification 22.214.171.124
Also Known as TLK1_HUMAN, TLK1, KIAA0137
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|718||ENSG00000198586||ENST00000442919, ENST00000521943||ENSP00000402165, ENSP00000428113||Q9UKI8-5|
UniProt: TLK1 is active in the following subcellular-locations: nucleus.
GO terms: TLK1 is active in the following subcellular-locations: nucleus.