TNIK (Q9UKE5) - Overview - Molecular Target Synopsis
TNIK, TRAF2 and NCK-interacting protein kinase
Enzyme Classification 18.104.22.168
Also Known as TNIK_HUMAN, TNIK, KIAA0551
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1.
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UniProt: TNIK is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus, recycling endosome.
GO terms: TNIK is active in the following subcellular-locations: apical plasma membrane, cytoplasm, cytoskeleton, cytosol, extracellular exosome, glutamatergic synapse, nucleoplasm, nucleus, postsynaptic density, presynapse, recycling endosome.