Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ERRFI1 (Q9UJM3) - Overview - Molecular Target Synopsis

Protein


ERRFI1, ERBB receptor feedback inhibitor 1
UniProt Q9UJM3

Also Known as ERRFI_HUMAN, ERRFI1, MIG6

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with ERBB2 (By similarity). Interacts with EGFR.

4ZJV
CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH MITOGEN- INDUCIBLE GENE 6 PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ERRFI1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ERRFI1 is active in the following subcellular-locations: cell membrane, cytoplasm, nucleus.
GO terms: ERRFI1 is active in the following subcellular-locations: cytoplasm, cytosol, extrinsic component of cytoplasmic side of plasma membrane, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ERRFI1 has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, PC_3, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, AGS, HCC364

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


For ERRFI1 there are:
7 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ERRFI1 has been screened with compounds ( bioactivities). (see details)