ATP5IF1 (Q9UII2) - Overview - Molecular Target Synopsis
ATP5IF1, ATPase inhibitor, mitochondrial
Also Known as ATIF1_HUMAN, ATP5IF1, ATPI, ATPIF1
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
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UniProt: ATP5IF1 is active in the following subcellular-locations: mitochondrion.
GO terms: ATP5IF1 is active in the following subcellular-locations: cell surface, mitochondrion.