Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO3A1 (Q9UIG8) - Overview - Molecular Target Synopsis

Protein


SLCO3A1, Solute carrier organic anion transporter family member 3A1
UniProt Q9UIG8

Also Known as SO3A1_HUMAN, SLCO3A1, OATP3A1, OATPD, SLC21A11

Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO3A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLCO3A1 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO3A1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, NCI_H322M, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DU4475, DMS 454, OVKATE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HeLa-S3, HSMM

(see details)


Screening and Chemistry


SLCO3A1 has been screened with 14 compounds (18 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)