Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRM2 (Q9UI43) - Overview - Molecular Target Synopsis

Protein


MRM2, rRNA methyltransferase 2, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q9UI43

Also Known as MRM2_HUMAN, MRM2, FJH1, FTSJ2

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

2NYU
CRYSTAL STRUCTURE OF HUMAN FTSJ HOMOLOG 2 (E.COLI) PROTEIN IN COMPLEX WITH S-ADENOSYLMETHIONINE
RCSB/PDB
Inspect Structure
See all 3D Structures for MRM2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MRM2 is active in the following subcellular-locations: mitochondrion.
GO terms: MRM2 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion, nucleolus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRM2 has gain in 6 cell-lines, loss in 3 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For MRM2 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis