Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NRBP1 (Q9UHY1) - Overview - Molecular Target Synopsis

Protein


NRBP1, Nuclear receptor-binding protein
UniProt Q9UHY1

Also Known as NRBP_HUMAN, NRBP1, BCON3, NRBP

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NRBP1 is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, endomembrane system, lamellipodium.
GO terms: NRBP1 is active in the following subcellular-locations: cell cortex, cytoplasm, endomembrane system, lamellipodium, membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NRBP1 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SF_539, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, OVMANA, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


NRBP1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TE8, TE10. (see details)


Screening and Chemistry


NRBP1 has been screened with compounds ( bioactivities). (see details)