Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A8 (Q9UHI5) - Overview - Molecular Target Synopsis

Protein


SLC7A8, Large neutral amino acids transporter small subunit 2
UniProt Q9UHI5

Also Known as LAT2_HUMAN, SLC7A8, LAT2

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC7A8 is active in the following subcellular-locations: basolateral cell membrane, cytoplasm.
GO terms: SLC7A8 is active in the following subcellular-locations: basolateral plasma membrane, cytoplasm, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A8 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, SK_MEL_5, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-140, SW 1417, KYSE-180

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, H1-hESC, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to SLC7A8 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A8 has been screened with compounds ( bioactivities). (see details)