Molecular Target Synopsis
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AFF4 (Q9UHB7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria7


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4OGR_G AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 56.9 26.2 Yes No
2 empty 1.98 52.4 10.1 No No
3 empty 2.78 64.5 6.6 No No
4 empty 2.84 59.1 6.2 No No
5 empty 2.27 64.5 7.7 No No
6 empty 2.6 59.8 6.2 No No
7 empty 3.01 64.1 6.3 No No
8 empty 2.91 53.9 5.8 No No
9 empty 2.98 72.6 6.3 No No
5JW9_A AF4/FMR2 family member 4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 65.9 17.4 No No
2 empty 2.21 61.7 17.7 No No
3 empty 2.24 53 7.8 No No
4 empty 2.63 48.6 6.4 No No
5 empty 2.29 69.6 6.3 No No
6 empty 2.76 48.1 7.1 No No
7 empty 2.68 59.1 6.6 No No
4IMY_H AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 59.4 26.6 Yes No
2 empty 2.21 49.4 8.4 No No
3 empty 1.8 53.4 8.5 No No
4 empty 3.07 59.9 10.4 No No
5 empty 2.67 60.5 5.5 No No
6 empty 2.79 49.3 5.8 No No
4OR5_E AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 58.4 26.8 Yes No
2 empty 1.74 54.5 9.9 No No
3 empty 2.49 56.7 11.9 No No
4 empty 2.52 48.1 10.8 No No
5 empty 1.95 62.7 7.8 No No
6 empty 2.72 58.7 8.9 No No
7 empty 1.98 51.2 6.1 No No
8 empty 2.94 61.6 5.3 No No
4OR5_J AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 57 26 Yes No
2 empty 2.67 52.3 11 No No
3 empty 1.84 53 10.5 No No
4 empty 2.7 45.4 9.6 No No
5 empty 1.87 60.3 11 No No
6 empty 2.72 67 7.5 No No
7 empty 3.01 62 4.8 No No
8 empty 3.12 58 6.2 No No
4IMY_G AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 58.7 26.4 Yes No
2 empty 1.87 55.6 10.9 No No
3 empty .68 57.6 5.1 No No
4OGR_C AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 60.7 25.4 Yes No
2 empty 1.91 49.6 10.7 No No
3 empty 2.8 61.9 9.7 No No
4 empty 3.16 66 6.9 No No
5 empty 2.44 44.4 8 No No
6 empty 2.48 41.1 6.6 No No
7 empty 3.41 52.9 7 No No
8 empty 1.87 62.6 5.3 No No
9 empty 2.53 44.1 7.2 No No
6R80_A AF4/FMR2 family member 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 71.9 30.8 Yes No
2 empty 2.35 63.1 22.1 No No
3 empty 2.32 52.9 14.7 No No
4 empty 2.01 67.2 21.6 No No
5 empty 2.3 64.2 19.6 No No
6 empty 2.28 58.7 20.9 No No
7 empty 1.91 71.1 11.9 No No
8 empty 2.03 63.2 25.6 No No
9 empty 2.45 63.1 16 No No
10 empty 1.98 65.4 13.2 No No
5L1Z_C AF4/FMR2 family member 4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 60.4 23.6 No No
2 empty 1.84 51.3 10.9 No No
3 empty 2.02 65.8 5.2 No No
4 empty 2.72 58.6 6.3 No No
5 empty 2.49 57.8 6.1 No No
6 empty 2.07 67.1 5.1 No No
7 empty 2.46 43.8 5.4 No No
4OGR_L AF4/FMR2 family member 4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 58.6 23 No No
2 empty 2.04 52.4 10.1 No No
3 empty 2.58 51.7 12.2 No No
4 empty 2.81 55.6 8 No No
5 empty 1.84 53.8 6.5 No No
6 empty 3.36 62.2 7.2 No No
7 empty 2.28 57 6.3 No No
8 empty 2.25 40.4 6.6 No No
4IMY_I AF4/FMR2 family member 4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 61.7 23.9 No No
2 empty 1.97 55.1 9.9 No No
3 empty 3.23 67.5 5.5 No No
4 empty 2.45 43.4 7.6 No No
5 empty 2.6 69.1 5.7 No No
6 empty 2.76 41.6 6 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


AFF4 is involved in 10 interactions in the network.


Druggability
Overall Druggability Percentile: 37.29
Druggability for Cancer Therapeutics: 57.13
Druggability for Other Therapeutics: 31.38
Cancer-Associated
Cancer-associated percentile : 81.57
Network Articulation Point
Is AFF4 critical for communication in the network?


Detailed Graph Legend:Help